Henry Keutmann, MD. Associate Professor of Medicine, Harvard Medical School and Research Staff Massachusetts General Hospital
Dr. Keutmann has over 30 years experience conducting NIH funded biochemical and structural studies of hormones and their receptors, including collaborations with Dr. Schneyer on how hormones bind receptors, and the design of inhibitors including activin and its inhibition by follistatin and FSTL3. Together with others, Drs. Schneyer and Keutmann produced a crystal structure of the FSTL3-activin complex that serves as reference point for analysis of the antibodies Fairbanks is producing to neutralize FSTL3. This experience will serve to aid Fairbanks in the design and testing of FSTL3 inhibitors.
Andrew Stewart, MD, Professor of Medicine, Endocrinology, Diabetes and Bone Disease and Director, Diabetes Obesity And Metabolism Institute, Mt Sinai Hospital
Dr. Stewart has made major contributions to understanding of regulation of beta cell proliferation in rodents and in humans. He has recently discovered small molecules that enhance human beta cell proliferation as potential novel diabetes treatments. Dr. Stewart has broad knowledge of beta cell biology as well as a deep clinical understanding of gaps in current diabetes treatments and will advise Fairbanks Pharmaceuticals on its therapeutic development program.
Daniel Bernard, PhD, Professor of Pharmacology and Therapeutics, McGill University
Dr. Bernard has elucidated the role of activin and related growth factors in control of reproductive hormone synthesis and secretion. He is an expert in the biochemistry, molecular biology, and genetics of the entire signaling system in this family of growth factors and his expertise will be valuable in determining mechanisms and optimizing function of Fairbanks Pharmaceuticals’ therapeutic candidates.
Laura Alonso, MD, Associate Professor of Medicine and Director of Beta Cell Biological Studies, University of Massachusetts Medical School
In addition to her clinical activities with diabetes patients, Dr. Alonso has an NIH-funded laboratory focused on mechanisms regulating beta cell function and proliferation. She and Dr. Schneyer have collaborated on several proposals to examine the mechanisms of activin action in regulating beta cell function. In addition, her expertise with mouse models of diabetes and insulin resistance makes her an excellent advisor for designing tests of candidate therapeutics developed by Fairbanks Pharmaceuticals.